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International Journal of Clinical Research. 2017; 1: (1) 1; DOI:10.20900/j.ijcr.20170001.

Mosapride combined with ziprasidone in the treatment of functional dyspepsia clinical observation of adverse effects associated with depression
莫沙必利结合齐拉西酮治疗功能性消化不良伴抑郁的临床效果观察

作者: 杨凌玲*,李继昌,马那琦,景艳艳

宝鸡市中心医院

宝鸡市中心医院

宝鸡市中心医院

宝鸡市中心医院

*通讯作者:杨凌玲,单位:宝鸡市中心医院;邮箱:yylianl@sina.com

引用本文: 杨凌玲,李继昌,马那琦,景艳艳. 莫沙必利结合齐拉西酮治疗功能性消化不良伴抑郁的临床效果观察. 国际临床研究杂志, 2017, 1(1)
Published: 2017-08-14

摘要

【摘要】目的:对莫沙必利结合齐拉西酮治疗功能性消化不良伴抑郁的临床效果进行研究和分析。
方法:选取我院2014年7月~2015年7月收治的功能消化不良伴抑郁患者共90例,随机分成对照组45例,应用莫沙必利治疗;观察组45例,应用莫沙必利结合齐拉西酮共同治疗。治疗5周后,对症状的消退情况进行观察比较。
结果:治疗前两组患者的汉密尔顿抑郁量表(HAMD)评分以及各症状积分差异无统计学意义,治疗后,观察组患者HAMD评分(2.1±0.2)分低于对照组HAMD评分(2.9±0.5)分,患者各症状积分均优于对照组,观察组的总有效率高达88.89%高于对照组的总有效率77.78%,组间比较,P<0.05。
结论:应用莫沙必利结合齐拉西酮对功能性消化不良伴抑郁患者进行治疗,有着较好的临床效果,副作用小,安全性高,可以在临床上推广应用。

关键词: 【关键词】莫沙必利;其拉西酮;功能性消化不良;抑郁;临床观察

Abstract

[Abstract] Objective: To observe the clinical effect of mosapride combined with ziprasidone in the treatment of functional dyspepsia patients with clinical depression .
Methods: A total of 90 patients were enrolled from our hospital during July 2014 to July 2015. They were randomly divided into control group (45cases) with mosapride and ziprasidone treatment or observation group (45 cases) with only mosapride treatment. After 5-week treatment, the symptoms were observed and compared.
Results: there was no significant difference in HAMD scores and symptom scores between the two groups before treatment. After treatment, the HAMD score in the observation group was significantly lower than that in the control group (0.2 V.S. 0.5). The total efficacy rate of the observation group was 88.89%, which higher than that of the control group, the total effective rate was 77.78%, P < 0.05.
Conclusion  : the administration of Mosapride combined with ziprasidone in the treatment of functional dyspepsia patients with depression showed good clinical effect, few side effects and high safety, it should be highly recommended in the clinical settings.

Key words: [keyword] Mosapride; the ziprasidone; functional dyspepsia; depression; clinical observation

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