International Journal of Clinical Research. 2019; 3: (1) 1; DOI:10.12208/j.ijcr.20190001.
目的：探讨和比较卡贝与欣母沛防治疤痕子宫再次剖宫产孕妇产后出血的临床疗效。方法：选择2017年2月到2018年7月我院收治的 78例疤痕子宫再次剖宫产孕妇，采用随机数字表法，将孕妇随机分为研究组和对照组，每组39例。研究组在胎儿取出后立即给予缩宫素 20 U 静滴、卡贝缩宫素子宫体肌肉注射，对照组则给予缩宫素 20 U 静滴和子宫体肌肉注射欣母沛。观察两组术中及产后 2 h、24 h 出血量，并比较分娩前后血红蛋白浓度，记录两组不良反应发生率。结果：两组产时、产后 2 h、24 h 出血量比较差异无统学计意义（P>0.05）。两组分娩前后血红蛋白浓度比较，差异无统计学计意义（P>0.05）。研究组不良反应发生率为12.82%（5/39），明显低于对照组的25.64%（10/29）（P<0.05）。结论：与欣母沛相比，卡贝缩宫素在疤痕子宫再次剖宫产预防产后出血方面有相同的疗效，且卡贝缩宫素不良反应较少。
Objective: To explore and compare the clinical efficacy of Carbetocin and Carboprost Tromethamine in preventing postpartum hemorrhage in pregnant women undergoing another cesarean section of scar uterus. Methods: From February 2017 to July 2018, 78 pregnant women admitted to our hospital for further cesarean section of scar uterus were selected, and the pregnant women were randomly divided into the study group and the control group, with 39 cases in each group. The study group received intramuscular injections of 20 U of oxytocin and Carbetocin immediately after removal of the fetus, while the control group received intramuscular injections of 20 U of oxytocin and the uterine muscle of Carboprost Tromethamine. Intraoperative and postpartum blood loss at 2 h and 24 h were observed in the two groups and hemoglobin concentrations before and after childbirth were compared to record the incidence of adverse reactions in the two groups. Results: There was no statistical significance (P>0.05) in the comparison of blood loss at birth, 2 h after delivery and 24 h after delivery. There was no statistically significant difference in hemoglobin concentrations before and after childbirth between the two groups (P>0.05). The adverse reaction rate in the study group was 12.82% (5/39), significantly lower than that in the control group (25.64% (10/29) (P<0.05). Conclusion : Compared with Carboprost Tromethamine, Carbetocin has the same curative effect in preventing postpartum hemorrhage by cesarean section of scar uterus, and Carbetocin has less adverse reactions.